Why Has the Antidepressant-Placebo Difference in Antidepressant Clinical Trials Diminished over the Past Three Decades?
نویسندگان
چکیده
منابع مشابه
A model of placebo response in antidepressant clinical trials.
Placebo response in clinical trials of antidepressant medications is substantial and has been increasing. High placebo response rates hamper efforts to detect signals of efficacy for new antidepressant medications, contributing to trial failures and delaying the delivery of new treatments to market. Media reports seize upon increasing placebo response and modest advantages for active drugs as r...
متن کاملAssessing the adequacy of past antidepressant trials: a clinician's guide to the antidepressant treatment response questionnaire.
Many depressed patients do not remit on antidepressant medication despite an adequate dosage and a sufficient duration of treatment.1 This has spawned endeavors to define treatment-resistant depression as a depressive episode that has shown insufficient response to 1 or more adequate trials of an antidepressant.1 What constitutes insufficient, inadequate, or partial response is still a matter o...
متن کاملDisclosing the potential impact of placebo controls in antidepressant trials
BACKGROUND Although placebo-control clinical trials that withhold effective treatments can be permissible, how best to inform participants of the placebo design has received little attention. AIMS To determine the effect of disclosing quantitative outcome estimates of individual treatment v. entering placebo-control randomised control trial (RCT) on willingness to enrol in such an RCT. METH...
متن کاملMeta-analysis of the placebo response in antidepressant trials.
UNLABELLED Improvements in placebo groups of antidepressant trials account for a major part of the expected drug effects. We aimed to determine overall effect sizes of placebo and drug effects in antidepressant trials, and to analyze whether the placebo effect in antidepressant trials also occurs for patient self-perception, general psychopathology, and quality of life. METHODS Search terms c...
متن کاملMisunderstanding of a New Approach to Drug-Placebo Difference Calculation in Short Term Antidepressant-Drug Trials
In clinical trials, drug effect is measured by a difference between subjects who are treated by experimental drug against placebo-treated subjects. In case of binary data, with observing YES/NO on each subject in certain period of time, it is the proportion of subjects who respond in treatment group minus the proportion of responders in placebo group (for example, 50% vs. 30%). However, a great...
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ژورنال
عنوان ژورنال: CNS Neuroscience & Therapeutics
سال: 2010
ISSN: 1755-5930
DOI: 10.1111/j.1755-5949.2010.00151.x